Can Ozempic Cause Pancreatitis? What You Should Know Before Taking

‍Ozempic, a medication for type 2 diabetes, has had great results in managing blood sugar and helping with weight loss.

However, it’s important to be aware of the associated risks and side effects, including the possibility of developing pancreatitis. 

Read on to discover if Ozempic causes pancreatitis, what the risk level is, possible causes of the pancreatitis, and more. 

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Does Ozempic Cause Pancreatitis?

Pancreatitis is inflammation of the pancreatic gland in the abdomen behind the stomach.

The two main functions of the pancreas are insulin and digestive enzyme production.

Acute pancreatitis comes on quickly and typically goes away in several days with proper treatment.

Chronic pancreatitis is when the pancreas does not get better with treatment and gradually worsens, and experiences permanent damage over time.

According to clinical trial results, several participants taking Ozempic developed pancreatitis.

However, the incidence was very rare, and some of the participants taking the placebo also developed pancreatitis. 

Despite the rare occurrence, the manufacturer of Ozempic lists pancreatitis under the Warnings and Precautions section of the prescribing information. 

They also instruct prescribing medical providers to observe their patients carefully for signs and symptoms of pancreatitis when taking Ozempic and to discontinue the medication immediately if suspected.

In the Indications and Usage section, the manufacturer clarifies that Ozempic has not been studied in people with a history of pancreatitis, and individuals who have previously had pancreatitis should consider an alternative medication for managing type 2 diabetes. 

What’s The Risk Of Pancreatitis While Taking Ozempic?

While the risk level is still being determined and requires more studies, here is what research shows so far.

Glycemic Control Trial

In one trial testing how well Ozempic helped control blood sugar, seven of the people taking Ozempic developed acute pancreatitis.

In contrast, only three in the group treated with other medications developed acute pancreatitis. 

The risk comparison from that study was 0.3 cases of acute pancreatitis per 100 patient years in the Ozempic group and 0.2 cases of acute pancreatitis per 100 patient years in the other medications group.

Only one case was reported of a person developing chronic pancreatitis.

Two-Year Trial

In a two-year trial, eight individuals taking Ozempic developed acute pancreatitis, while ten of the placebo group developed acute pancreatitis. 

The risk comparison from this study was 0.27 cases per 100 patient years for the Ozempic group, and 0.33 cases for 100 patient years for the placebo group.

So it’s clear that while there is a risk of developing acute pancreatitis while taking Ozempic, that risk level is still very low and, in some cases, was higher in the alternative group. Chronic pancreatitis appears to be very rare. 

Potential Causes Of Pancreatitis While Taking Ozempic

Experts are still looking into what may cause pancreatitis while taking Ozempic. 

What is known is that the medication acts on the pancreas by encouraging insulin secretion when you eat.

It also slows the speed at which food empties from the stomach, possibly affecting digestive enzymes and the pancreas.

However, these explanations are guesses at this point, and more research is needed to learn how Ozempic may contribute to the development of pancreatitis. 

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Factors That Increase Pancreatitis Risk

Several factors can increase your risk of developing pancreatitis, whether related to Ozempic or due to underlying health conditions and lifestyle choices. 

Common risk factors of pancreatitis include:

• Alcohol misuse.
• Smoking.
• Gallstones.
• High cholesterol.
• Abdominal injury.
• Endoscopic procedure (ERCP).
• Drugs.
• Autoimmune disorders.
• Genetic factors.
• Infections.

If you have a high risk of developing pancreatitis or have had pancreatitis in the past, it’s recommended to discuss alternative diabetic management options with your medical provider.

Symptoms Of Pancreatitis

Symptoms of acute pancreatitis can vary from mild to severe and may include:

• Pain in the upper abdomen that spreads to the back.
• Fever.
• Nausea and vomiting.
• Rapid pulse.
• Tenderness when touching the abdomen.
• Swollen abdomen.

Can You Prevent Pancreatitis While Taking Ozempic?

While you may not be able to entirely eliminate the risk of pancreatitis while taking Ozempic, you can take several steps to reduce the risk.

• Discuss your complete medical history with your healthcare provider: Discuss the risks and benefits of taking the medication and how your medical history may influence your risk level.
• Follow the dosage schedule: Strictly adhere to your healthcare provider's treatment plan, and do not adjust the dose without medical supervision.
• Avoid or limit alcohol consumption: Alcohol misuse is a significant risk factor for developing pancreatitis.
• Stop smoking: Smoking is associated with having a higher risk of developing pancreatitis.
• Stay hydrated: Keeping yourself hydrated helps your body function properly.
• Eat a balanced diet: Focus on eating lean proteins, fruits and vegetables, whole grains, and healthy fats to reduce any strain on your pancreas.
• Monitor your cholesterol level: Keep up with regularly checking your cholesterol levels and taking any medications your medical provider orders to keep it in balance.
• Schedule regular follow-ups: See your medical provider for all follow-up appointments and notify them of any suspicious symptoms.

Other Ozempic Risks And Contraindications

Aside from the minimal risk of pancreatitis, Ozempic has several more common side effects including:

• Nausea.
• Vomiting.
• Diarrhea.
• Abdominal or stomach pain.
• Constipation.

Other less common but more severe side effects include:

• Changes in vision.
• Low blood sugar.
• Kidney problems.
• Allergic reaction.
• Gallbladder problems.

Ozempic also has a warning for the possible risk of thyroid c-cell tumors based on animal studies.

If you have a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, do not take Ozempic as it’s contraindicated.

If you plan on getting pregnant or are breastfeeding, discuss alternative options with your provider, as the risk to the baby and fetus is unknown. 

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Takeaway

While the risk of pancreatitis while taking Ozempic is small, it’s still important to be aware of it and to watch for possible symptoms.

If you have a history of pancreatitis, it’s recommended that you avoid Ozempic and find an alternative method of managing your blood sugar.

If you take Ozempic, certain steps such as smoking cessation, avoiding alcohol, adhering to the dosing protocol, and discussing your medical history with your medical provider are several ways you can reduce your risk of complications from Ozempic, such as pancreatitis.

Other more common side effects of Ozempic include nausea, vomiting, stomach pain, diarrhea, and constipation. 

Regular follow-ups and open communication with your medical provider can help you stay safe and achieve your health goals.

How A Dietitian Can Help

While taking Ozempic, a Nourish dietitian can be a valuable asset in helping you optimize your blood sugar management and weight loss while reducing the stress on the pancreas. 

Registered dietitians are experts in the field of how food affects your blood sugar and aid in weight management.

They can also help you with tips on alleviating gastrointestinal side effects of Ozempic, such as nausea or changes in bowel habits.

By having a wide range of nutritional knowledge, a Nourish dietitian can create a customized eating plan that considers your preferences while meeting your nutritional needs and enhancing the effectiveness of Ozempic.

Find a Nourish dietitian who accepts your insurance.

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